Closed mostly within the Weddell Sea Subarea 48.5 is one of the closed data-poor CCAMLR subareas, where stock assessment should be carried out. In spite of hard ice conditions during most of the time of the year, this large water area is very similar with the Ross Sea. This similarity, which could be found in geographical location, bathymetric profile and current system, highlight the Weddell Sea as one of the most promising area for exploratory fishery of Dissostichus sp. However, fishery in subarea 48.5 is closed on the basis data on stock absence. The main objective of the present program is collecting data for reliable stock assessment and following estimation of precautionary limits in accordance with CCAMLR decision rules. The program contains schedule and research program of the second stage of Russian Federation multi-year research program in the Weddell Sea that are prospected for 3-5 years. Detailed plan of fishing operations, collecting and analysis of data will be provided for the Scientific Committee and Commission consideration.