Closed mostly within the Weddell Sea Subarea 48.5 is one of the closed data-poor CCAMLR subareas, where stock assessment should be carried out. In spite of hard ice conditions at most part of the Sea during mostly all the year, this large water area is very similar to the Ross Sea. This similarity could be found in geographical location, bathymetric profile, currents system and follows from results of the first and the second stage of this program. It highlights the Weddell Sea as one of the most promising area for exploratory fishery of Dissostichus sp. However, fishery in Subarea 48.5 is closed on the basis data on stock assessment absence. The main objective of the present program is collecting data for reliable stock assessment and following estimation of precautionary limits in accordance with CCAMLR decision rules. The program contains schedule and research program of the third stage of the Russian multi-year research program in the Weddell Sea that is prospected for 3-5 years. Detailed plan of fishing operations, data collecting and analysis will be provided for the Scientific Committee and Commission consideration.